Next generation GBR: Stabilization of bovine bone grafts and long-lasting pericardium membranes

Prof. dr. sc. Daniel Rothamel

O radionici: One of the most challenging procedures in implantology is the predictable and safe regeneration of lateral and vertical bone defects. Besides autogenous bone as the golden standard for jaw augmentation procedures, different biomaterials such as bone substitutes and membranes have shown predictable results especially in lateral grafting applications. In contrast to the patient´s own bone, the use of biomaterials is not accompanied by donor site morbidity, leading to high patient acceptance. However, the use of bone substitutes is accompanied by the risk of volume loss, soft tissue ingrowth and incomplete graft regeneration. Bovine bone substitutes have shown excellent volume maintenance and osseoconductive support of bone formation. The use of pericardium-based collagen membranes allows for long barrier function but still maintaining advantages of the native collagen structure such as biocompatibility, tissue integration, nutrition transfer and graft stabilization. However, quality of the recipient site, the osteogenicity of the graft, immobilization technique and a transmembraneous angiogenesis of the barrier and the selected healing time are also affecting the predictability of the regeneration outcome.